EventsThe 11th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-11-01341
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 11th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2007
Citation
E. Vicente, R. Villar, A. Burguete, B. Solano, S. Pérez-Silanes, I. Aldana, L. Vivas, A. Monge, Synthesis and Structure-Activity Relationship of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives against Plasmodium falciparumclick to see Communication, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01341
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Synthesis and Structure-Activity Relationship of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives against Plasmodium falciparumclick to see Communication

E. Vicente 1,2
R. Villar 1
A. Burguete 1
B. Solano 1
S. Pérez-Silanes 1
I. Aldana 1
L. Vivas 2
A. Monge 1
1. Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología, Aplicada (CIFA), University of Navarra, 31080 Pamplona, Spain.
2. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, (LSHTM), Keppel Street, London WC1E 7HT, United Kingdom
Abstract
The aim of this study was to identify new active compounds against Plasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2- carbonitrile 1,4-di-N-oxide derivatives. Antimalarial activity was evaluated in vitro against Plasmodium falciparum (3D7 and K1 strains) by the incorporation of [ 3 H]hypoxanthine. Cytotoxicity was tested in KB cells by Alamar Blue assay. Twelve compounds were synthesized and evaluated for antimalarial activity. Eight of them showed a IC 50
Keywords
n/a
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