Synthesis of some new N-acyl derivatives of ferrocenyl pyrazolines and investigation of their cytotoxic effect

For several years, ferrocene moiety represents a significant part of the structure of different biologically active compounds. Ferrocene is stable and non-toxic compound and as such very useful for various syntheses. The combination of pharmacologically active N-heterocycles with ferrocene mostly leads to a favorable change in biological properties in a huge number of drugs. Considering the importance of these properties, this article describes the synthesis and characterization of a new series of ferrocenyl pyrazolines in good yields. Screening of the new products in vitro against human cervical cancer cells (HeLa), human breast cancer cells (MDA-MB-231), human colon cancer cells (HCT-116), and human fibroblast (MRC-5, as control cells) by the MTT method was performed.