Events8th International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ECMC2022-13492 (registering DOI)
This submission belongs to the session S3. General of the event 8th International Electronic Conference on Medicinal Chemistry
Published date
07 Nov, 2022
Academic Editor
author-avatarMaria Emília Sousa
Citation
Emina Mrkalić, Miroslav Sovrlić, Marina Ćendić Serafinović, Ratomir Jelić, Nevena Prodanović, Investigation on the interaction between lurasidone and human serum albumin, in Proceedings of 8th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2022-13492
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Investigation on the interaction between lurasidone and human serum albumin

Emina Mrkalić 1
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Miroslav Sovrlić 2
Marina Ćendić Serafinović 3
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Ratomir Jelić 2
Nevena Prodanović 2
1. University of Kragujevac, Institute for Information Technologies, Department of Science, Jovana Cvijića bb, Kragujevac 34000, Serbia
2. University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, Kragujevac 34000, Serbia
3. University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovića 12, Kragujevac 34000, Serbia
Abstract

Lurasidone hydrochloride is a second-generation (atypical) antipsychotic agent who is used for the treatment of schizophrenia and bipolar depression. The mechanism of action of lurasidone is not completely elucidated, assumed to affect dopamine and serotonin receptors, but is devoid of antihistaminic or anticholinergic activities [1].

Human serum albumin (HSA), the most abundant transport protein in blood plasma, consisting of 585 aminoacids residues and have three binding sites (I, II and III) [2,3]. The most of drugs binds to hydrophobic cavities in subdomains IIA and IIIA, in the site I and II, respetively. Investigation the interactions of drugs to HSA may give useful informations of effectiveness of drugs.

In this study, we investigate interactions between lurasidone and human serum albumin (HSA) by the fluorescence quenching technique, synchronous fluorescence spectroscopy and molecular docking.

Keywords
Lurasidone
human serum albumin
fluorescence spectroscopy
molecular docking
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