Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session e. Symposium on Microwave Assisted Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

Sachin S. Laddha, Satayendra P. Bhatnagar, Efficient Niementowski synthesis of novel derivatives of 1,2,9,11-tetrasubstituted-7H-thieno[2',3':4,5]pyrimido[6,1-b]-quinazolin-7-one, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01351

Facebook

Twitter

Efficient Niementowski synthesis of novel derivatives of 1,2,9,11-tetrasubstituted-7H-thieno[2',3':4,5]pyrimido[6,1-b]-quinazolin-7-one

Sachin S. Laddha ¹

Satayendra P. Bhatnagar ¹

1. Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India

Abstract

Starting Starting from 5,6-disubstituted-3H-thieno[2,3-d]pyrimidin-4-ones, novel 1,2,9,11-tetrasubstituted-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-ones could be reached in two steps through a von Niementowski reaction, which involves condensation of substituted anthranilic acids with a 4-chloro-5,6-disubstituted-3H-thieno[2,3-d] pyrimidines. Microwave irradiation in acetic acid media was used in order to improve reactions where conventional heating was limited.

Keywords

cyclization

fused thieno-[2,3-d]-pyrimidine

Microwave assisted synthesis

Sulphur heterocycles

Expedite regioselective synthesis of pyrimidobenzimidazoles

A Novel Microwave Synthesis of Unsubstituted Cyclic Imides