Events The 26th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 26th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2022

Academic Editor

Julio A. Seijas

Citation

Alexey Makarov, Lilya Dzhemileva, Elina Makarova, Usein Dzhemilev, Development of new effective methods for the synthesis of lembehynes A–C exhibiting cytotoxic and neuritogenic activity, in Proceedings of The 26th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-26-13524

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Development of new effective methods for the synthesis of lembehynes A–C exhibiting cytotoxic and neuritogenic activity

Alexey Makarov ¹

Lilya Dzhemileva ²

Elina Makarova ¹

Usein Dzhemilev ²

1. IPC RAS

2. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Abstract

The report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented in the report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (Dzhemilev reaction) at the key stage of the synthesis.

Keywords

Lembehynes A-C

1Z,5Z-dienes

cross-cyclomagnesiation

anticancer and neuritogenic activity

Manuscript

sciforum_063429_original_Makarov_A_A.pdf

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Synthesis of 1,3-diyne derivatives of lembehyne B with antitumor and neuritogenic activity.