EventsThe 26th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-26-13525
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 26th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2022
Academic Editor
author-avatarJulio A. Seijas
Citation
Elina Makarova, Lilya Dzhemileva, Alexey Makarov, Usein Dzhemilev, Synthesis of 1,3-diyne derivatives of lembehyne B with antitumor and neuritogenic activity., in Proceedings of The 26th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-26-13525
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Synthesis of 1,3-diyne derivatives of lembehyne B with antitumor and neuritogenic activity.

Elina Makarova 1
Lilya Dzhemileva 2
Alexey Makarov 1
Usein Dzhemilev 2
1. IPC RAS
2. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Abstract

The report presents data on our studies on obtaining lembehyne B derivatives with cytotoxic and neuritogenic activity. The methods and approaches to the synthesis of the above-mentioned lembehynes presented in the report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (the Dzhemilev reaction) at the key stage of the synthesis.

Keywords
Lembehyne B
1Z,5Z-dienes
cross-cyclomagnesiation
anticancer and neuritogenic activity.
Manuscript
sciforum_063434_original_Makarova_E_Kh.pdf
Development of new effective methods for the synthesis of lembehynes A–C exhibiting cytotoxic and neuritogenic activity
Development and Validation of RP-UHPLC Method for Determination of Sertraline in Bulk Drug and Dosage Form