EventsThe 26th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-26-13552
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 26th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2022
Academic Editor
author-avatarJulio A. Seijas
Citation
Carlos jesús Cortés-García, Gabriela Servín García, Luis Chacón-García, Joaquín González Marrero, Mariana Macías Alonso, Mario Armando Gómez Hurtado, Gabriela Rodríguez García, Rosa E. del Río, Semisynthesis of 6β-acetoxyvouacapane derivates via the Ugi-azide multicomponent reaction, in Proceedings of The 26th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-26-13552
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Semisynthesis of 6β-acetoxyvouacapane derivates via the Ugi-azide multicomponent reaction

Gabriela Servín García 1,2
Luis Chacón-García 3
Joaquín González Marrero 4
Mariana Macías Alonso 4
Mario Armando Gómez Hurtado 2
Gabriela Rodríguez García 2
Rosa E. del Río 2
Carlos jesús Cortés-García 3
1. laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58030, Morelia, Michoacán, México
2. laboratorio de Productos Naturales, Instituto de Investigaciones Químico Biológicas, Universidad Michoaca-na de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58030, Morelia, Michoacán, México
3. laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México
4. Instituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Ingeniería Campus Guanajuato, Av. Mineral de Valenciana 200 Col. Fracc. Industrial Puerto Interior, Silao 36275, Guanajuato, Mexico
Abstract

A semisynthesis of 6β-acetoxyvouacapane-1,5-disusbtituted tetrazoles derivates from the leaves of Caesalpinia platyloba by using the Ugi-azide multicomponent reaction as a key step reaction is described. To our knowledge, this is the first report where a non-natural product such as 1,5-disusbtituted tetrazole is linked to a natural product or derivate of a natural product, and beyond the biological relevance that the target molecules present, this work contributes to the area of natural products as well as multicomponent reactions

Keywords
6β-acetoxyvouacapane
1,5-disusbtituted tetrazoles
Ugi-azide
isocyanides
semisynthesis
Manuscript
sciforum_066416_original_26th_ECSOC.pdf
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