EventsThe 26th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-26-13553
This submission belongs to the session S1. General Organic Synthesis of the event The 26th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2022
Academic Editor
author-avatarJulio A. Seijas
Citation
Leandro Gabriel Gutierrez, Ana Paula Reinick, Carla Maria Ormachea, Vanina Alejandra Guntero, Cristián Alejandro Ferretti, Use of oxidative coupling strategy as a means to increase in vitro antioxidant activity of vanillin derivatives, in Proceedings of The 26th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-26-13553
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Use of oxidative coupling strategy as a means to increase in vitro antioxidant activity of vanillin derivatives

Leandro Gabriel Gutierrez 1
Ana Paula Reinick 1
Carla Maria Ormachea 1
Vanina Alejandra Guntero 2
Cristián Alejandro Ferretti 1
1. Group of Organic Synthesis and Materials (GSOM), Laboratorio Fester – Química Orgánica (FIQ), Ins-tituto de Química Aplicada del Litoral (IQAL) (UNL-CONICET), Universidad Nacional del Litoral, Santa Fe, Argentina.
2. 1 Group of Organic Synthesis and Materials (GSOM), Laboratorio Fester – Química Orgánica (FIQ), Ins-tituto de Química Aplicada del Litoral (IQAL) (UNL-CONICET), Universidad Nacional del Litoral, Santa Fe, Argentina. 2 Group of Natural Products and Materi
Abstract

The aim of this study was to investigate the antioxidant properties in vitro of three different vanillic dimers (Compounds 1a-c). They were synthesized through an oxidative coupling strategy in good yields. The targeted compounds were found to be highly active for the total antioxidant assay, as well as for the lipid peroxidation test. All investigated compounds exhibited superior or comparable antioxidant capacity in comparison to precursor vanillin, proving that the oxidative coupling is a great strategy to increase antioxidant behavior of vanillin derivatives

Keywords
vanillic dimers
oxidative coupling
antioxidant activity
Manuscript
sciforum_066421_original_ECSOC_2022_Gutierrez.pdf
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