Synthesis of bis-amides employing a plant-derived triterpenoid as component in the Ugi reaction

Herein we describe the synthesis of a series of four novel triterpenoid-derived bis-amides employing masticadienonic acid from Pistacia mexicana, as carboxylic acid component in the Ugi reaction. Products were obtained via a facile and efficient one-pot procedure, under mild green conditions, with moderate yields (29-58%). The stereo-electronic nature of the aldehyde component influences the reaction yields.