Nickel-catalyzed, one pot synthesis of pyrazoles

Recently, multi-component, one-pot reactions have been shown to be efficient and environmentally friendly methods compared to traditional linear-step syntheses. It is novel, complex and functionally dense heterocyclic molecules. Pyrazole moieties are ubiquitous in organic compounds and have a wide range of pharmacological activities, such as antitumor, antifungal, and analgesic activities. Therefore, compounds containing pyrazole rings are widely used in the fields of medicine and life sciences. In addition, pyrazoles have also shown applications in the preparation of organometallic complexes, supramolecular and electroluminescent materials, and as essential ligands for metals. Due to their excellent properties, extensive efforts have been made to construct pyrazole derivatives. Over the past few decades, various methods of constructing pyrazoles have been developed. But the most common strategy is condensation reaction between hydrazine and a 1,3-electrophilic substrate to obtain pyrazole derivatives. Therefore, the synthesis of pyrazole derivatives is an important issue. In the present work, we have described a new, efficient and environment benign synthetic method for the formation of pyrazoles through one-pot method using heterogeneous catalysis.