Events The 26th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session S1. General Organic Synthesis of the event The 26th International Electronic Conference on Synthetic Organic Chemistry

Published date

18 Nov, 2022

Academic Editor

Julio A. Seijas

Citation

Richard T Taylor, Rebecca G Brunner, Depolymerization of heparin benzyl ester in a flow system, in Proceedings of The 26th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-26-13718

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Depolymerization of heparin benzyl ester in a flow system

Richard T Taylor ¹

Rebecca G Brunner ²

1. Department of Chemistry and Biochemistry, Miami University, Oxford, OH USA, Tonga

2. Department of Chemistry and Biochemistry, Miami University, Oxford, OH USA

Abstract

The preparation of enoxaparin via the base promoted depolymerization is well known. In this paper we present our efforts to convert this preparation into a flow method, Streams of base and ester solutions are combined and heated in a flow reactor, Variations in flow rate, temperature and residence time were examined.

NMR analysis demonstrates that careful control of the reaction parameters affords enoxaparin-like material. Analysis was carried out by NMR spectroscopy and optimum conditions determined.

Keywords

Heparin

enoxaparin

flow reaction

Manuscript

sciforum_066983_original_ECSOC_manuscript.pdf

Oral Presentation

Powerpoint.pptx

Poster

Powerpoint.pdf

Theoretical studies and computer modeling of supramolecular chemical systems: structure, properties and reactivity

Nanoencapsulation of 3-chloropropylaminobenzoate derivatives with potential insecticidal activity