An accidental explosion can cause severe damage to the structure and its inhabitants. Then, this paper provides an interesting comprehensive, Comprehensive Blast Analysis (CBA), to demonstrate the severity of non-structural elements by analyzing the structural and non-structural responses. For the structural response, the acceleration response was measured and represents the absorbed energy of the main structure affected by fragments of non-structural elements by using the concept of Arias intensity. For non-structural elements, the kinetic energy of fragments was used to express the severe damage to people. Moreover, the Applied Elements Method (AEM) was used to interpret the numerical outcomes of structural and non-structural responses. The purpose of the current study is to compare the severity of outer-cladding materials, which are brick and reinforced concrete walls, damaged to the residual structure and inhabitants.