Events The 13th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 13th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Oct, 2009

Citation

M. Sameiro T. Gonçalves, Susana P. G. Costa, Ana M. S. Soares, 4-(Hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran-ß-alanine conjugate: synthesis and photocleavage, in Proceedings of The 13th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2009, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-13-00139

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4-(Hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran-ß-alanine conjugate: synthesis and photocleavage

M. Sameiro T. Gonçalves ¹

Susana P. G. Costa ¹

Ana M. S. Soares ¹

1. Centro de Química, Universidade do Minho, Gualtar, 4710-057 Braga, Portugal

Abstract

The novel functionalised oxygen heterocycle 4-(hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran was synthesised and used in the preparation of a fluorescent ß-alanine conjugate. In order to evaluate its photosensitivity, photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300 and 350 nm) was carried out and photocleavage kinetic data were obtained.

Keywords

Photocleavable protecting groups

Benzopyrans

Neurotransmitter amino acids

A photolabile amino acid building block based on a new fluorescent functionalised coumarin-6-yl-alanine

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