EventsThe 10th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-10-01398
This submission belongs to the session a. General Organic Synthesis of the event The 10th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2006
Citation
Pavol Kois, Ivana Kosiova, Synthesis of Novel Coumarin Based Fluorescent Probes, in Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2006, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-10-01398
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Synthesis of Novel Coumarin Based Fluorescent Probes

Ivana Kosiova 1
Pavol Kois 1
1. Comenius University, Faculty of Natural Sciences, Department of Organic Chemistry, Mlynska dolina, Pavilon CH2, SK-84215 Bratislava, Slovak Republic
Abstract
We report on synthesis of new fluorescent probes suitable for site specific incorporation into oligonucleotides. Coumarin derivatives (1-5) were used as sensitive fluorescent labels and two linkers (6-7) were attached to the basic coumarin skeleton for further applications. Spectral characteristic of functionalized coumarin derivatives (8-10,13-14) were measured and derivative with the best fluorescent properties was chosen. Phosporamidite derivative 17 was prepared from functionalized coumarin derivative 9.
Keywords
coumarin
labeling
phosphoramidite
oligonucleotide
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