Events Cells, Cells and Nothing but Cells: Discoveries, Challenges and Directions

Event submissions

Published

This submission belongs to the session CELLS_S1. Stem Cells of the event Cells, Cells and Nothing but Cells: Discoveries, Challenges and Directions

Published date

02 Mar, 2023

Academic Editor

Alexander E. Kalyuzhny

Citation

Graziella Pellegrini, Eleonora Maurizi, Development of therapies for the two sides of the cornea, in Proceedings of Cells, Cells and Nothing but Cells: Discoveries, Challenges and Directions, 6 March–8 March 2023, MDPI: Basel, Switzerland

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Development of therapies for the two sides of the cornea

Graziella Pellegrini ¹

Eleonora Maurizi ²

1. University of Modena and Reggio Emilia, Centre for Regenerative Medicine "Stefano Ferrari", Switzerland

2. University of Modena and Reggio Emilia, Centre for Regenerative Medicine "Stefano Ferrari"

Abstract

The clearness of the cornea is essential for visual acuity and is guaranteed by limbal stem cell regeneration of the outer specialized epithelium and by the integrity of the inner corneal endothelium.

Limbal Stem Cell Deficiency (LSCD) leads to multiple corneal abnormalities including visual loss. Autologous Cultivated Limbal Stem Cell Transplantation is the first stem cell treatment for LSCD, approved at EU level. Here we present the results from the first EU multicenter clinical trial on EU citizens and a following step for the future restoration of other corneal areas, specifically the corneal endothelium.

Keywords

corneal epithelium

limbal stem cell deficiency

EU multicenter clinical trial

corneal endothelium

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