EventsThe 10th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-10-01416
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 10th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2006
Citation
Ewan Boyd, Sameer Chavda, Jason Eames, Probing The Resolution of 2-Alkoxy and 2-Aryloxy Carboxylic Acids, in Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2006, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-10-01416
Share
Email
Facebook
Twitter
LinkedIn

Probing The Resolution of 2-Alkoxy and 2-Aryloxy Carboxylic Acids

Ewan Boyd 1
Sameer Chavda 2
Jason Eames 2
1. Syngenta, Grangemouth Manufacturing Centre, Earls Road, Grangemouth, FX3 8XG, Scotland
2. Department of Chemistry, The University of Hull, Kingston Upon Hull, HU6 7RX, UK
Abstract
The separation of enantiomeric substrates using a parallel kinetic resolution strategy is becoming increasingly popular. 1 In recent years, attention has focussed on the use of traditional chiral auxilaries as complementary quasi-enantiomeric resolving agents. 2 In particular, Davies, 3 has elegantly shown the parallel kinetic resolution of the racemic enone (rac)-1 using a pair of quasi-enantiomeric lithium amides (S)-2 and (R)-3 to give the corresponding syn,syn,antiadducts 4 and 5 with near perfect levels of complementary stereocontrol (Scheme 1).
Keywords
n/a
New Synthesis of 4,4'-Diethylaminoethoxyhexestrol dihydrochloride (Coralgil) and scaling up to multi-grams scale
Probing the Parallel Kinetic Resolution of Racemic Oxazolidinones using Quasi-enantiomeric Profens