EventsThe 10th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-10-01417
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 10th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2006
Citation
Gregory S. Coumbarides, Marco Dingjan, Jason Eames, Tony Flinn, Northern Northen, Yonas Yohannes, Probing the Parallel Kinetic Resolution of Racemic Oxazolidinones using Quasi-enantiomeric Profens, in Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2006, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-10-01417
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Probing the Parallel Kinetic Resolution of Racemic Oxazolidinones using Quasi-enantiomeric Profens

Gregory S. Coumbarides 1
Marco Dingjan 1
Jason Eames 1,2
Tony Flinn 3
Northern Northen 3
Yonas Yohannes 1
1. Department of Chemistry, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
2. Department of Chemistry, The University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK
3. Onyx Scientific Limited, Units 97-98, Silverbriar, Sunderland Enterprise Park East, Sunderland, SR5 2TQ, UK
Abstract
The separation of enantiomeric substrates using a parallel kinetic resolution is becoming increasingly popular.1 In recent years, attention has focussed on the use of traditional chiral auxiliaries as complementary quasi-enantiomeric resolving agents. 2 In particular, Davies, 3 has elegantly shown the parallel kinetic resolution of the racemic enone (rac)-1 using a pair of quasi-enantiomeric lithium amides (S)-2 and (R)-3 to give the corresponding syn,syn,anti-adducts 4 and 5 with near perfect levels of complementary stereocontrol (Scheme 1).
Keywords
n/a
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