EventsThe 10th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-10-01421
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 10th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2006
Citation
Jaroslaw Polanski, Jacek Finster, Barbara Podeszwa, Dominik Tabak, Katarina Kralova, Josef Jampilek, Robert Musiol, Substituted Amides of Quinoline Derivatives: Preparation and Their Photosynthesis-inhibiting Activity, in Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2006, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-10-01421
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Substituted Amides of Quinoline Derivatives: Preparation and Their Photosynthesis-inhibiting Activity

Robert Musiol 1
Josef Jampilek 2
Katarina Kralova 3
Dominik Tabak 1
Barbara Podeszwa 1
Jacek Finster 1
Jaroslaw Polanski 1
1. Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland
2. Zentiva a.s., U kabelovny 130, 102 37 Prague 10, Czech Republic
3. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia
Abstract
The series of nine amides of substituted 8-hydroxyquinolines were prepared. The synthetic procedures of compounds are presented. All the prepared quinoline derivatives were analyzed using RP-HPLC method for the lipophilicity measurement and their lipophilicity were determined. The prepared compounds were tested for the reduction of chlorophyll content in Chlorella vulgaris Beij. Several compounds showed biological activity comparable with or higher than the standard 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well as structure-activity relationships (SAR) between the chemical structure and the biological activities of the evaluated compounds.
Keywords
Quinoline derivatives
Lipophilicity
Reduction of chlorophyll content
<i>Chlorella vulgaris</i>
Structure-activity relationships
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