Events The 10th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 10th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2006

Citation

Supanna Techasakul, Supa Hannongbua, Suda Louisirirotchanakul, Pornpan Pungpo, Nitirat Chimnoi, Nisachon Khunnawutmanothum, Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase, in Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2006, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-10-01422

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Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Nisachon Khunnawutmanothum ¹

Nitirat Chimnoi ¹

Pornpan Pungpo ²

Suda Louisirirotchanakul ³

Supa Hannongbua ⁴

Supanna Techasakul ^1,4

1. Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand

2. Department of Chemistry, Faculty of Science, Ubonratchathani University, Ubonratchathani 34190, Thailand

3. Department of Microbiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

4. Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand

Abstract

Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing unsubstituted lactam nitrogen and 2- chloro-8-arylthiomethyl were synthesized via efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.

Keywords

n/a

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