Events The 10th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 10th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2006

Citation

M. S. T. Gonçalves, C.V. P. Moura, M. J. Sousa, V. H. J. Frade, Antimicrobial evaluation of benzo[a]phenoxazine heterocycles: structure–activity relationships, in Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2006, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-10-01428

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Antimicrobial evaluation of benzo[a]phenoxazine heterocycles: structure–activity relationships

V. H. J. Frade ¹

M. J. Sousa ²

C.V. P. Moura ¹

M. S. T. Gonçalves ¹

1. Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

2. Centro de Biologia, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Abstract

A series of functionalised 5,9-diaminobenzo[a]phenoxazinium salts, in the free form or linked to L-glycine and L-valine amino acids were evaluated against Saccharomyces cerevisiae, in a microdilution broth assay. The results obtained showed that these compounds exhibited antifungal activity depending on the substituents of the 5,9-diaminobenzo[a]phenoxazine nucleous. The best activities were obtained when substituents at the positions 9 and 10 were NHEt, and Me, respectively, and at the position 5, NH(CH₂)₃Cl or NH(CH₂)₃CO₂Et.

Keywords

n/a

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