Study on the use of Xanthohumol and its derivatives as potential agent in the treatment of breast cancer

Cancer consists of disordered cell growth leading to changes in the genetic code. These conditions may be related to genetic factors or inadequate lifestyle conditions. Breast cancer is the second most common cancer in the world and the most common among women. According to the National Cancer Institute (INCA), at least one third of new cases of cancer that occur in the world annually could be prevented. The treatment of breast cancer can be arduous and painful both for the patient and the family members due to the symptoms and reactions of the same, so the treatment must be administered by a multidisciplinary team aiming at a comprehensive and humanized treatment for the patient. In general, the treatment modality is between surgery, radiotherapy and chemotherapy and hormone therapy. Faced with the occurrence and trauma left by existing conventional treatments, many studies have been carried out on the use of natural products in the treatment of diseases, including anticarcinogenic activities. These applications are often justified by the high toxicity of the drugs used. Natural chalcones can be found in vegetables, flowers and leaves, chemically, it is an α,β–unsaturated ketone. Data from 2016 from SciFinder record the existence of 92,000 chalcones from natural sources. The synthesis of chalcones has aroused interest in this area because it is considered a privileged structure due to its C6- C3-C6 skeleton, which in the chemistry of natural products arouses great pharmacological interest in the its versatility, structural variety and acceptance of substitutes, which makes the compounds obtained from its synthesis have diverse pharmacological properties, such as analgesic, anti-inflammatory, antibacterial, antituberculosis, antidiabetic, antioxidant, antiviral action, among others. Natural chalcones can be found in vegetables, flowers and leaves. Xanthohumol is a chalcone originally found in the hard resin (lupulin) of the female flower of Humulus Lupulus, known and used industrially as an agent responsible for the aroma, bitterness and natural preservative of beer. Xanthohumol has been extensively studied for its antiinflammatory, antioxidant and anticarcinogenic properties. It undergoes thermal isomerization to isoxanthohumol, as well as 8- and 6-prenylnaringenin. The in-silico study dealt with in this summary, bring the action of Xanthohumol in the activity of combating breast cancer by means of docking molecular.