Events The 9th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 9th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2005

Citation

S. Jhaumeer Laulloo, A. Khodaboccus, U. Hemraz, S. Sunnassee, Studies towards Use of Di-tert-butyl-dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides, in Proceedings of The 9th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2005, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-9-01489

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Studies towards Use of Di-tert-butyl-dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides

S. Jhaumeer Laulloo ¹

A. Khodaboccus ²

U. Hemraz ¹

S. Sunnassee ¹

1. Department of Chemistry, University of Mauritius, Réduit, Mauritius

2. Boehringer Ingelheim Pharmaceuticals, Ste 205 Virginia Biotech Research Park, Richmond, VA 23219, USA

Abstract

Amide formation from amino acids was achieved in an easy and convenient one-pot procedure in chloroform or tetrahydrofuran as solvent using di-tert-butyl dicarbonate both as a protecting and an activating agent in the absence of a catalyst or coupling reagent. A number of dipeptide has been thus synthesized in good yields. The structures of the dipeptides were confirmed by IR, NMR and mass spectral data.

Keywords

Di-tert-butyl-dicarbonate

activation of carboxylic group

amino protecting-group

amide formationDi-tert-butyl-dicarbonate

activation of carboxylic group

amino protecting-group

amide formation

New Different Synthetic Approaches to the Isoindoloisoquinolone Skeleton. Total Synthesis of Nuevamine

Enantiopure Tetrahydrofuranols by Radical Cyclization Reactions. A Simple Entry into Isodideossinucleosides