EventsThe 9th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-9-01501
This submission belongs to the session b. Solid Phase Chemistry and Combinatorial Synthesis of the event The 9th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2005
Citation
Piotr Lulinski, Dorota Maciejewska, Magdalena Bamburowicz-Klimkowska, Miroslaw Szutowski, Preliminary Evaluation of Molecularly Imprinted Polymer Synthesized with Dopamine Hydrochloride as a Template, in Proceedings of The 9th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2005, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-9-01501
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Preliminary Evaluation of Molecularly Imprinted Polymer Synthesized with Dopamine Hydrochloride as a Template

Piotr Lulinski 1
Dorota Maciejewska 1
Magdalena Bamburowicz-Klimkowska 2
Miroslaw Szutowski 2
1. Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland
2. Department of Toxicology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland
Abstract
A new easy approach to separation of dopamine hydrochloride is reported. The molecularly imprinted polymer (MIP) was used as the adsorbent material. The MIP was prepared employing dopamine hydrochloride as a template and methacrylic acid (MAA) with ethylene glycol dimethacrylate (EDMA) in co-polymerization process. Non-covalent prearrangement between dopamine hydrochloride and methacrylic acid in organic porogen prior to bulk polymerization was utilized. Preliminary chromatographic results showed that dopamine hydrochloride could be retained by the polymer and then eluted using optimized elution protocol. The interactions between template and monomers were proposed of the basis of semiempirical PM3 theoretical calculation.
Keywords
molecularly imprinted polymers
dopamine hydrochloride
solid phase extraction
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