Events The 9th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 9th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2005

Citation

Robert Musiol, Josef Jampilek, Katarina Kralova, Barbara Podeszwa, Jacek Finster, Halina Niedbala, Anna Palka, Jaroslaw Polanski, New Quinoline Derivatives Possessing Herbicidal Activity, in Proceedings of The 9th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2005, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-9-01508

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New Quinoline Derivatives Possessing Herbicidal Activity

Robert Musiol ¹

Josef Jampilek ²

Katarina Kralova ³

Barbara Podeszwa ¹

Jacek Finster ¹

Halina Niedbala ¹

Anna Palka ¹

Jaroslaw Polanski ¹

1. Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland

2. Zentiva a.s., U kabelovny 130, 10237 Prague 10, Czech Republic

3. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia

Abstract

The series of quinoline derivatives were prepared. The synthetic procedures of compounds are presented. All the prepared derivatives were analyzed using the reversed phase high performance liquid chromatography (RP-HPLC) method for the lipophilicity measurement. In the present study the correlation between RP-HPLC retention parameter Log K (the logarithm of capacity factor K) and various calculated Log P data is shown. The prepared compounds were tested for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Structure-activity relationships between the chemical structure and the biological activities of the evaluated compounds are discussed.

Keywords

quinoline derivatives

styrylquinoline analogues

photosynthesis inhibition

lipophilicity

structure-activity relationships

Chlorella vulgaris

spinach chloroplasts

Chromatographic and Computational Study of Hydrophobic Properties of Ring Substituted Pyrazinecarbonitriles and Acetylpyrazines

Access to a Key Intermediate for the Synthesis of 1-thia-analogue of Quercetin