Events 9th International Electronic Conference on Medicinal Chemistry

Event submissions

Published

10.3390/ECMC2023-15631 (registering DOI)

This submission belongs to the session S3. General of the event 9th International Electronic Conference on Medicinal Chemistry

Published date

01 Nov, 2023

Academic Editor

Maria Emília Sousa

Citation

Petar Biljana Stanić, Radoslav Zoran Pavlović, Sanja Lj Matić, Biljana Šmit, Jovica Bađić, Newly synthesized deep-cavity basket 1³⁻ as potential DNA protective agent against oxidative damage, in Proceedings of 9th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2023, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2023-15631

Facebook

Twitter

Newly synthesized deep-cavity basket 1^3- as potential DNA protective agent against oxidative damage

Sanja Lj Matić ¹

Biljana Šmit ¹

Petar Biljana Stanić ¹

Radoslav Zoran Pavlović ²

Jovica Bađić ³

1. Department of Sciences, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia, Serbia

2. Northwestern University, 633 Clark St, Evanston, IL 60208, USA, USA

3. Ohio State University, 281 W Lane Ave, Columbus, OH 43210, USA, USA

Abstract

A novel vase-shaped molecular basket 1^3-, consisting of a deep nonpolar pocket of three napthalimide molecules fused to a bicyclic base, with polar glycine residues at the top was synthesized. Biocompatibility of the synthesized molecular basket was examined in vitro. The possible in vitro DNA protective potential of the newly synthesized deep-cavity basket 1^3- at several concentrations (25, 50, 100, 200, and 400 μg/mL) was investigated against hydroxyl and peroxyl radicals-induced DNA damage. Basket at lower concentrations (25, 50, 100 μg/mL) almost completely protected DNA against hydroxyl and peroxyl radicals induced DNA damage. It can be concluded that the newly synthesized molecular basket in the range of concentrations tested showed a significant DNA-protective potential against oxidative modifications of DNA caused by the harmful effects of free radicals.

Keywords

molecular baskets

cavitand

biocompatibility

DNA protection

Manuscript

P. Stanic ECMC9 Revised.pdf

Development of an LC-MS/MS-based method for quantification Tdp1 inhibitor based on usnic acid and distribution study in tissue of healthy and tumor mice

Brain targeting: optimisation and biocompatibility of valproic acid-loaded nanostructured lipid carriers (VPA-NLC) for nose-to-brain delivery

Newly synthesized deep-cavity basket 13- as potential DNA protective agent against oxidative damage

Newly synthesized deep-cavity basket 1^3- as potential DNA protective agent against oxidative damage