The importance of selected adipokines in the diagnosis of neuroendocrine neoplasms of various locations.

Adipose tissue performs important endocrine functions. In the case of obesity, which is associated with chronic inflammation, the balance in the release of adipokines is disturbed. Metabolic disorders of adipose tissue may contribute to the development and progression of cancer, including neuroendocrine neoplasms (NENs). The aim of this study was to determine the concentration of leptin, omentin-1, visfatin and resistin in healthy people and in patients with NENs of the gastrointestinal tract, pancreas and lung. The study included 68 patients of the Prof. F. Łukaszczyk Oncology Center in Bydgoszcz with NENs of the gastrointestinal tract (GT, n=34), NENs of pancreas (PA, n=22), NENs of lungs (L, n=12) and in the control group (CTRL, n=35). The concentration of the adipokines was measured by the enzyme immunoassay method using ready-made ELISA kits and Bio-Plex Pro Human Diabetes. A statistical analysis was performed and P<0.05 was considered as statistically significant. The results were presented as the mean value and the standard error of the mean. There were statistically significant changes in the levels of visfatin and resistin in patients with NENs compared to CTRL, but no statistically significant difference was found in the concentration of leptin, an adipokine responsible for regulating the body's energy storage. The concentrations of the measured adipokines were similar in the analyzed subgroups of NENs. However, a statistically significant increase in omentin-1 concentration was observed in patients with NENs, the only tested adipokine with anti-inflammatory activity, which may have a prognostic significance.