Porous material for antimicrobial applications based on beta-cyclodextrin and maltol derivative

The use of metal chelating agents has made it possible to prevent critical biological processes in microbial cells, interrupting the vital metal metabolism of the microorganism, hindering metal absorption and bioavailability for critical reactions. Over the years, nanotechnological development has made a wide range of nanomaterials is available for possible uses in the antibacterial field. This complex field is shaped by antimicrobial nanoparticles, which are also being studied as therapeutic and drug delivery tools. Specifically, a novel drug delivery system based on the beta-cyclodextrin-maltol derivative was designed and manufactured. HEMA (hydroxyethyl methacrylate) monomer/maltol derivative was synthesized and co-polymerized with beta-cyclodextrin acrylic monomer. The 3D porous materials containing hydrophobic cavities were loaded with lomefloxacin, resulting in optimal drug loading efficiency while maintaining iron chelating ability. This system has been extensively characterized using different techniques such as: NMR, IR, SEM and EDX. This unconventional approach was successfully designed as a proof of concept of a dual-action antibacterial nanomaterial with lomefloxacin and iron-depleting properties achieved by maltol derivative.