One-pot synthesis of tetrazole-triazole bis-heterocycles via Ugi-Azide reaction

Bioisosteres of amide bonds such as 1,5-disubstituted-1,2,3-triazoles (1,5-DS-1,2,3-Ts) and 1,5-disubstituted tetrazoles (1,5-DST) are present in compounds with important biological activities like antineoplastic, antibacterial, antifungal and antiparasitic; and antifungal, antiparasitic, antiviral, and anti-inflammatory, respectively. In the present work, we present the synthesis of tetrazole-triazole bis-heterocycles via Ugi-Azide strategy. Bis-heterocycles were synthesized with moderate yields, under mild conditions, employing 2H-1,2,3-triazole aldehyde.