Synthesis and characterization of hybrid structures based on furan-2(3H)-ones and chromen-4(4H)-ones - potential antibacterial activity

Introduction

Currently, in the development of new biologically active compounds, a trend is developing towards the concept of molecular hybridization, which consists in combining two or more pharmacophoric fragments in one molecule. From this point of view, chromen-4(4H)-ones and furan-2(3H)-ones are promising starting compounds.

Experimental details

3-{[2-Oxo-5-arylfuran-3(2H)-ylidene]methyl}-4H-1-benzopyran-4-ones were synthesized by the reaction of equimolar amounts of 5-arylfuran-2(3H)-ones with 3-formylchromone in glacial acetic acid with good yields. The composition and structure of all compounds were characterized by a set of spectroscopic methods (IR, NMR).

Results and Discussion

By screening various reaction conditions, we found that using the Monowave 50 reactor resulted in increased product yields as well as significantly improved reaction efficiency Based on NMR, it was shown that the resulting compounds exist only in the form of E-isomers.