Ultrasound-assisted Ugi-Azide Multicomponent Reaction for the synthesis of 1,5-Disubstituted Tetrazoles

The Ugi-Azide MCR (UA) is one of the most efficient methods for the synthesis of 1,5-disubstituted-1H-tetrazoles (1,5-DS-T). Complex drug-like scaffolds incoporating tetrazoles have demostrated a wide range of therapeutic benefits such as anti-inflammatory, antiviral, antibiotics, anti-ulcer, anxiety and anti-hypertensive agents, attributable to their mimetic cis amide of peptide bonds enhance metabolic stability, selectivity and other beneficial physicochemical properties, in addition to their applications in bioimaging, photoimaging and coordination chemistry, Herein we present the ultrasound-assisted sustainable synthesis of six novel 1,5 DS-T under solvent-free conditions.