Multicomponent, Solvent‐free Synthesis of 4-substituted aminopyrido[2,3-d]pyrimidine derivatives

pyrido[2,3-d]pyrimidine ring structure is one of the most interesting heterocycles in drug design, these later witch containing this moiety have various pharmacological activities such as antitumor, antipyretic, antihypertensive, antifungal, antibacterial, and anti-inflammatory activities. More specifically pyrido[2,3-d]pyrimidines were considered as inhibitors of dihydrofolate reductases (DHFR), tyrosine kinases and adenosine kinase. Moreover, the synthesis of these fused heterocyclic compounds provides an interesting challenge in medicinal chemistry.
In this work, we present a simple and efficient synthesis of pyrido[2,3-d]pyrimidines via multicomponent reaction under solvent-free conditions.