EventsThe 27th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-27-16092
This submission belongs to the session S1. General Organic Synthesis of the event The 27th International Electronic Conference on Synthetic Organic Chemistry
Published date
15 Nov, 2023
Academic Editor
author-avatarJulio A. Seijas
Citation
DIANA GARCÍA-GARCÍA, RICARDO RAMIREZ HERNANDEZ, MANUEL A. RENTERÍA-GÓMEZ, ROCÍO GÁMEZ-MONTAÑO, Ugi-4CR/SN2-cyclization strategy for the one-pot synthesis of 2,5-diketopiperazines, in Proceedings of The 27th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2023, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-27-16092
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Ugi-4CR/SN2-cyclization strategy for the one-pot synthesis of 2,5-diketopiperazines

DIANA GARCÍA-GARCÍA 1
RICARDO RAMIREZ HERNANDEZ 1
MANUEL A. RENTERÍA-GÓMEZ 1
ROCÍO GÁMEZ-MONTAÑO 1
1. Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato 36050, México., Mexico
Abstract

2,5-diketopiperazines (2,5-DKPs) are the smallest cyclic peptides in nature and display a variety of bioactivities including antibacterial, antifungal, and anticancer, which are well documented pharmacophore. The one-pot synthesis of 2,5-DKPs is few reported. Herein, we report a novel one-pot synthesis of 2,5-DKPs via Ugi-4CR/SN2-cyclization strategy, under mild conditions, ethanol was used as a solvent for both procedures.

Keywords
2,5-DKPs
IMCR
Ugi-4CR
bis-amide
Manuscript
sciforum-081964-clean.pdf
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