Events The 27th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 27th International Electronic Conference on Synthetic Organic Chemistry

Published date

15 Nov, 2023

Academic Editor

Julio A. Seijas

Citation

Ilgam Gaisin, Ilgiz Ilshatovich Islamov, lilya Dzemileva, Usein Dzemilev, Synthesis of Aromatic Macrodiolides and Study of Their Antitumor Activity In Vitro, in Proceedings of The 27th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2023, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-27-16102

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Synthesis of Aromatic Macrodiolides and Study of Their Antitumor Activity In Vitro

Ilgam Gaisin ¹

Ilgiz Ilshatovich Islamov ¹

lilya Dzemileva ²

Usein Dzemilev ²

1. Institute of Petrochemistry and Catalysis, RAS Russia, Russia

2. N.D. Zelinsky Institute of Organic Chemistry RAS, Russia

Abstract

Based on (5Z,9Z)-tetradeca-5,9-diene-1,14-dioic acid previously undescribed polyether aromatic macrodiolides were synthesized in good yields (53-67%). The cytotoxicity of the resulting macrocyclic compounds in vitro against tumor Jurkat, K562, conditionally normal Hek293 cell lines and normal fibroblasts was assessment carried out. The ability of the most active macrodiolide to induce apoptosis towards Jurkat cells and influence the cell cycle was studied.

Keywords

1,5-Dienoic compounds

homo-cyclomagnesiation

Grignard reagents

Macrodiolides

Crown ether

Manuscript

sciforum-081940-clean.pdf

Preparation of a Fluorescent Peptide Substrate to Target Tumor-associated Macrophages

A new synthesis of poly heterocyclic compounds containing nitrogen and boron atoms