EventsThe 27th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-27-16155
This submission belongs to the session S3. Microwave Assisted Synthesis of the event The 27th International Electronic Conference on Synthetic Organic Chemistry
Published date
15 Nov, 2023
Academic Editor
author-avatarJulio A. Seijas
Citation
Didier Villemin, Renata Gasparova, Nathalie Bar, Microwave activation: solventless catalysed synthesis of cross conjugated dienones of Tropinone., in Proceedings of The 27th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2023, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-27-16155
Share
Email
Facebook
Twitter
LinkedIn

Microwave activation: solventless catalysed synthesis of cross conjugated dienones of Tropinone.

Renata Gasparova 1
Didier Villemin 2
Nathalie Bar 2
1. Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie J. Herdu 2, Trnava, Slovak Republic, Slovakia
2. Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Normandie, 14050 Caen, France, France
Abstract

Abstract:

Cross-conjugated dienones exhibit important biologically activities. Furthermore, tropane derivatives constitute a very known class of bioactive alkaloids(atropine, cocaine...). The condensation of N-methyl-8-azabicyclo[3.2.1]-heptan-3-one (Tropinone) with aromatic aldehydes takes place in the presence of acidic (clay K10, silica) or basic catalysts (alumina, KF-alumina). The best yields of (2E,4E)-2,4-bis-arylmethylene-8-methyl-8-azabicyclo[3.2.1]heptan-3-ones were obtained with the K10 clay under microwave irradiation without solvent.

Keywords
cross-conjugated dienones
tropinone
microwave
clay catalysis
KF-alumina.
Manuscript
sciforum-080789-clean.pdf
Poster
tropoP1023.pdf
tropoP1023.pdf
Clay catalysis: solventless condensation of 3-coumaranones with 1,2--dicarbonyl compounds under microwave irradiation. Synthesis of new acylaurones.
Larvicidal Potency of Some Selected Nigerian Plants against Aedes aegypti