Synthesis of pyrrole derivatives through multicomponent reaction strategy in the presence of new heterogeneous catalyst based on chitosan

The aim of this study is to synthesis of pyrrole derivatives based on phenacyl bromide and amine, which is promoted by a green and heterogeneous chitosan-based catalyst under optimal laboratory conditions through the multi-component reaction strategy namely Hantzsch pyrrole synthesis. This bio-based CS-EDTA-THEIC network contains appropriate basic and acidic active sites to act as a multifunctional catalyst. Indeed, the CS-EDTA-THEIC nanomaterial used in the multicomponent reaction for synthesis of pyrrole derivatives showed excellent yields in short reaction times. Furthermore, the CS-EDTA-THEIC network, as a heterogeneous catalyst, illustrated magnificent reusability and can be used at least six times without significant loss of its activity.