Events The 9th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session e. Symposium on Microwave Assisted Synthesis of the event The 9th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2005

Citation

Jennifer M. Kremsner, C. Oliver Kappe, Ulrich Jordis, Klaus Gerdes, Development of Multi-Gram Scale Microwave Assisted Organic Synthesis (MAOS): Suzuki Coupling towards 2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan), in Proceedings of The 9th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2005, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-9-01637

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Development of Multi-Gram Scale Microwave Assisted Organic Synthesis (MAOS): Suzuki Coupling towards 2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan)

Klaus Gerdes ¹

Ulrich Jordis ¹

C. Oliver Kappe ²

Jennifer M. Kremsner ²

1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria

2. Institute of Chemistry, Karl Franzens Universität Graz, Heinrichstrasse 28, 8010 Graz, Austria

Abstract

The improved synthesis of 2,4-dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d] pyrimidin-7-one (tasosartan-1, click for 3D-structure) on multigramscale is described. The synthesis was developed in context of the DrugMatrix-genomics project.

Keywords

angiotensine II antagonist

Suzuki-coupling

microwave

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