Liquid crystal gel based on sensitive pH and temperature composites

In this work, a liquid crystal system as a potential bone-repairing booster has been induced from a polyacrylic acid (PAAc) gel loaded with synthetic hydroxyapatite nanoparticles (nHA) under physiological conditions of pH and temperature that resemble the early stages of bone formation. Dynamic processes at the microscale in biological systems require a material capable of behaving following a specific order and fluency. Besides, they must fulfill conditions such as biocompatibility. The occurrence of mesophases at different environments of pH and temperature has been shown by an optical microscope with crossed polaroids and retardation plate. The biocompatibility has been demonstrated by hemolysis analysis and coagulation assays. The results have shown a biocompatible system with excellent adaptation properties under physiological in vitro conditions.