Application of information technology in optimization of combined metabolitotropic cardioprotection

Cardiovascular diseases are one of the most serious problems of modern medicine. Creation of combinations of metabolitotropic cardioprotectors selectively affecting individual target links of ischemic cascade of myocardial damage with the involvement of information technologies is a new promising approach. The aim of the study: to determine experimentally the approaches to the directed metabolic pharmacocorrection of ischemic myocardium and to develop the principles of combined prescription of metabolitotropic cardioprotectors on the basis of the created information technology of computer prediction. We have developed the basic theoretical concepts of a new scientific complex methodology with the involvement of information technologies for the selection and creation of drug combinations of metabolitotropic agents with improved pharmacological and toxicological properties for metabolitotropic cardioprotection. The obtained results were used in the development of an expert system for in silico substantiation of rational combinations of metabolitotropic drugs. The expert system was developed in the form of web application. The obtained data became theoretical and experimental substantiation for the creation of combined drugs based on L-arginine, glycine, tryptophan, L-lysine. The application of new information technology in the targeted development of rational combinations of metabolitotropic drugs will increase the efficiency of complex therapy of cardiovascular diseases of ischemic genesis.