Events The 2nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 2nd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1998

Citation

Wolfgang Stadlbaur, Gerhard Hojas, Werner Fiala, Thermal Cyclization of 2-Hydrazonoacyl-3-oxo-heterocycles to Pyrazolo[4,3-c]fused Heterocycles, in Proceedings of The 2nd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1998, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-2-01669

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Thermal Cyclization of 2-Hydrazonoacyl-3-oxo-heterocycles to Pyrazolo[4,3-c]fused Heterocycles

Wolfgang Stadlbaur ¹

Gerhard Hojas ¹

Werner Fiala ¹

1. Institute of Organic Chemistry, Karl-Franzens University Graz, Austria

Abstract

1-Aryl-pyrazolo[4,3-c]quinolin-3-ones 1 reveal interesting structures because of their potential biological activity [1]. A binding study on bovine brain membranes has shown that 1-aryl- pyrazolo[4,3-c]quinolin-3-ones 1 bearing different substituents at position 4 possess activity in displacing specific [3H]flunitrazepam from its receptor site [2]. In this paper we present new strategies for the synthesis of 1-aryl- or 2-arylamino-pyrazolo[4,3-c]fused heterocycles such as 1-aryl-pyrazolo[4,3-c]fused quinolines and coumarins having hydrogen-, methyl- or aryl-substituents at position 3. The cyclization conditions were studied by differential scanning calorimetry (DSC).

Keywords

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