Events The 2nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Combinatorial Synthesis, Parallel Synthesis and Automation of the event The 2nd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1998

Citation

Cyprian O. Ogbu, Maher N Qabar, P. Douglas Boatman, Jan Urban, Joseph P. Meara, Mark D. Ferguson, John Tulinsky, Chris Lum, Suresh Babu, Mark. A. Blaskovich, Hiroshi Nakanishi, Fuqiang Ruan, Bolong Cao, Ryan Minarik, Tom Little, Sherry Nelson, Minh Nguyen, Anna Gall, Michael Kahn, Highly efficient and versatile Synthesis of Libraries of constrained b-strand Mimetics, in Proceedings of The 2nd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1998, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-2-01688

Facebook

Twitter

Highly efficient and versatile Synthesis of Libraries of constrained b-strand Mimetics

Cyprian O. Ogbu ¹

Maher N Qabar ¹

P. Douglas Boatman ¹

Jan Urban ¹

Joseph P. Meara ¹

Mark D. Ferguson ¹

John Tulinsky ¹

Chris Lum ¹

Suresh Babu ¹

Mark. A. Blaskovich ¹

Hiroshi Nakanishi ^1,2

Fuqiang Ruan ¹

Bolong Cao ¹

Ryan Minarik ¹

Tom Little ¹

Sherry Nelson ¹

Minh Nguyen ¹

Anna Gall ¹

Michael Kahn ^1,2

1. Molecumetics Ltd., 2023 120th Avenue NE, Bellevue,WA 98005-2199, U.S.A.

2. University of Washington, Department of Pathobiology,SC-38, Seattle, WA 98195, U.S.A.

Abstract

The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels-Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libraries of compounds that mimic the b-strand secondary structure of proteins. Several potent and selective inhibitors of proteases have been discovered

Keywords

n/a

The "Portioning-Mixing" (Split-Mix) Synthesis

Parallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch and Release" Strategy