Events The 2nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Medicinal and Bioorganic Application of Organic Synthesis of the event The 2nd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1998

Citation

W. D. Woggon, H. Aissaoui, R. Bachmann, C. Claude, A. Schweiger, H. A. Wagenknecht, Synthetic Active Site Analogues of Heme-Thiolate Proteins Catalysis and Identification of Elusive Intermediates, in Proceedings of The 2nd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1998, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-2-01694

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Synthetic Active Site Analogues of Heme-Thiolate Proteins Catalysis and Identification of Elusive Intermediates

W. D. Woggon ¹

H. Aissaoui ¹

R. Bachmann ²

C. Claude ¹

A. Schweiger ²

H. A. Wagenknecht ¹

1. Institut für Organische Chemie der Universität Basel, St. Johanns- Ring 19, CH-4056 Basel, Switzerland

2. Laboratorium für Physikalische Chemie, Eidgenössische Technische Hochschule, CH-8092 Zürich

Abstract

Intermediates of the catalytic cycles of chloroperoxidase and cytochrome P450cam are identified and characterized by means of synthetic enzyme models.

Keywords

chloroperoxidase · chlorination · cytochrome P450 . enzyme model · EPR-ENDOR-spectroscopy . heme-thiolate protein · iron porphyrin

A Chemical Synthesis of Porphobilinogen Imitating the Pathway Proposed by Shemin for the Biosynthesis: Comparing Inhibition Studies with Investigations of Chemical Reactivity

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