Events The 2nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Medicinal and Bioorganic Application of Organic Synthesis of the event The 2nd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1998

Citation

Miroslav Miletin, Jiri Hartl, Martin Dolezal, Zelmira Odlerova, Katarina Kralova, Milos Machacek, Synthesis of Some 2,6-Disubstituted 4-Pyridinecarboxamides and -Carbothioamides, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity, in Proceedings of The 2nd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1998, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-2-01695

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Synthesis of Some 2,6-Disubstituted 4-Pyridinecarboxamides and -Carbothioamides, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

Miroslav Miletin ¹

Jiri Hartl ¹

Martin Dolezal ¹

Zelmira Odlerova ²

Katarina Kralova ³

Milos Machacek ⁴

1. Department of Medicinal Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic

2. Institute of Preventive and Clinic Medicine, Bratislava, Slovak Republic

3. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic

4. Department of Inorganic and Organic chemistry, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic

Abstract

A group of 26 new 6-halogeno- or 6-alkylsulfanyl-2-alkylsulfanylpyridine-4-carboxamides and corresponding carbothioamides was synthesised. Some of the amides and all thioamides were tested for their antimycobacterial activity against atypical mycobacterial strains. Promising photosynthesis-inhibiting activity was also found for some of the amides.

Keywords

Pyridininecarbothioamides

antimycobacterial activity

photosynthesis-inhibiting activity.

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