EventsThe 2nd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-2-01699
This submission belongs to the session c. Medicinal and Bioorganic Application of Organic Synthesis of the event The 2nd International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 1998
Citation
Ivan V. Micovic, M. D. Ivanovic, Vesna D. Kiricojevic, Sonja Vuckovic, Ljiljana Dosen-Micovic, The Synthesis and Pharmacological Evaluation of 2,3 "seco" Fentanyl, in Proceedings of The 2nd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1998, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-2-01699
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The Synthesis and Pharmacological Evaluation of 2,3 "seco" Fentanyl

Ivan V. Micovic 1
M. D. Ivanovic 2
Vesna D. Kiricojevic 2
Sonja Vuckovic 3
Ljiljana Dosen-Micovic 1
1. Department of Chemistry, University of Belgrade, Studentski trg 16. P.O Box 550, Yu-550 11001, Belgrade, FR Yugoslavia
2. Institute for Chemistry, Technology and Metalurgy, Center for Chemistry, Studentski trg 16, 11001, Belgrade, FR Yugoslavia
3. Department of Pharmacology, Toxicology and Clinical Pharmacology, Medical Faculty, P.O. Box 662
Abstract
A structurally novel, 2,3 seco analogue of fentanyl has been synthesized by a short and efficient procedure. Central-analgesic activity was found to be ca. 30 times lower than fentanyl but still several times higher than morphine.
Keywords
Fentanyl
open-chained analogues
central analgesics
Dansyl-labeled heterobifunctional crosslinker with NHS-ester and protected sulfhydryl groups
Design and Synthesis of a Photoaffinity Label for the Enzyme Tocopherol Cyclase