EventsThe 3rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-3-01744
This submission belongs to the session a. General Organic Synthesis of the event The 3rd International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 1999
Citation
Ramachandra S. Hosmane, Huanming Chen, Maria Bretner, Base-Pairing Studies of a Ring-Expanded ("Fat") Nucleoside Analogue Possessing Potent Antiviral Activity., in Proceedings of The 3rd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1999, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-3-01744
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Base-Pairing Studies of a Ring-Expanded ("Fat") Nucleoside Analogue Possessing Potent Antiviral Activity.

Maria Bretner 1
Huanming Chen
Ramachandra S. Hosmane 1
1. Laboratory for Drug Design and Synthesis, Department of Chemistry & Biochemistry University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle Baltimore, Maryland 21250, USA
Abstract
Ring-expanded ("fat") nucleosides and nucleotides are potentially useful probes for nucleic acid metabolism, structure, and function. With their structural resemblance to natural purines, they are a rich source of substrates or inhibitors of enzymes of nucleic acid metabolism as well as of those requiring energy cofactors such as ATP or GTP. As ring-expansion is anticipated to considerably affect the electronic, spatial, and geometric characteristics, they are also excellent probes for steric and conformational constraints of nucleic acid double-helices.
Keywords
1H NMR Studies
Base-Pairing Properties
Ring-Expanded ("Fat" Nucleoside)
A Versatile Synthetic Precursor for Introduction of Specific N6-Modifications in 2,6-Diaminopurine Nucleosides:N2-Acetyl-2',3',5'-tri-O-acetyl-N6-(1,2,4-triazol-1-yl)- 2,6-diaminopurine-9--D-ribofuranoside.
Synthesis of Novel Acyclic Nucleoside and Acyclic Nucleoside Phosphonate Analogues of a Ring-Expanded ("Fat") Nucleobase Containing the Imidazo[4,5-e][1,3]diazepine Ring System.