Events The 3rd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 3rd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1999

Citation

Anatoly D. Shutalev, A New Route for the Synthesis of Cyclic Thioureas and Related Compounds, in Proceedings of The 3rd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1999, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-3-01751

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A New Route for the Synthesis of Cyclic Thioureas and Related Compounds

Anatoly D. Shutalev ¹

1. Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Avenue 86, Moscow 117571, Russia

Abstract

Six-membered cyclic thioureas can be prepared by a convenient stereoselective method based on the reduction of readily available 4-hydroxy(or 4-alkoxy)hexahydropyrimidine-2-thiones or 1,2,3,4-tetrahydropyrimidine-2-thiones with NaBH4 - CF3COOH. Alternative method of the preparation of the target compounds includes reaction of 4-azido-, 4-acetoxy- or 4-arylsulfonylhexahydropyrimidine-2-thiones with NaBH4.

Keywords

hexahydropyrimidine-2-thiones/ones

1,2,3,4-tetrahydropyrimidine-2-thiones

tetrahydro-1,3-thiazine-2-thiones

sodium tetrahydroborate - trifluoacetic acid

Phthalides and Chromones from 4-Coumarinacetic acids, Study of Beneficial Effects of Microwave Irradiation on Synthesis.

Color Encoded Parallel Synthesis