Events The 3rd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Medicinal and Bioorganic Application of Organic Synthesis of the event The 3rd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1999

Citation

Pieter Jan Gerrits, Johannes Brussee, Arne van der Gen, Substrate Transport Limitation as tool to enhance enantioselectivity in the enzyme synthesis of chiral cyanohydrins, in Proceedings of The 3rd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1999, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-3-01763

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Substrate Transport Limitation as tool to enhance enantioselectivity in the enzyme synthesis of chiral cyanohydrins

Pieter Jan Gerrits ¹

Johannes Brussee ¹

Arne van der Gen ¹

1. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, NL-2300 RA Leiden, The Netherlands

Abstract

Objective: Rational design of process characterized by: two-phase (fed) batch system, the use of purified oxynitrilase, enantiomerically pure products (ee > 98%), high yield and through-put (mol.l-1.h-1), down stream processing with respect to recycling of enzyme and solvents

Keywords

n/a

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