Events The 3rd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Medicinal and Bioorganic Application of Organic Synthesis of the event The 3rd International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 1999

Citation

Dejan Opsenica, Gabriela Pocsfalvi, Zorica Juranic, Bogdan Solaja, Steroidal Tetraoxanes - New Class of Antitumor Compounds, in Proceedings of The 3rd International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1999, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-3-01769

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Steroidal Tetraoxanes - New Class of Antitumor Compounds

Dejan Opsenica ¹

Gabriela Pocsfalvi ²

Zorica Juranic ³

Bogdan Solaja ⁴

1. Institute of Chemistry, Technology and Metallurgy, Belgrade

2. Centro Internazionale di Servizi di Spettrometria di Massa del C.N.R, Naples

3. Institute for Oncology and Radiology of Serbia, Belgrade

4. Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 158, YU-11001 Belgrade, Yugoslavia

Abstract

Cholic acid derived steroidal tetraoxanes possessing methyl ester, carboxylic acid, primary and secondary amide termini were synthesised and their in vitro antitumor activity against Fem-X and HeLa cell cultures was determined. IC50 range between 3.1 and 166 M. Five out of seven tested compounds exhibited cell rounding and / or apoptic activity. Their liquid secondary ionization (LSI) and electronspray ionization (ESI) spectra confirmed the tetraoxane structure.

Keywords

Steroids

cholic acid

tetraoxanes

LSIMS

ESI

antitumor activity

Synthesis of Glycosyl Phosphoramidates: Novel Isosteric Analogs of Glycosyl Phosphates

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