Events The 13th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 13th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2009

Citation

Walid Fathalla, Ibrahim A. I. Ali, Synthesis of N-substituted-3,4,5,6-tetrachlorophthalimide using trichloroacetimidate C-C bond formation method, in Proceedings of The 13th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2009, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-13-00180

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Synthesis of N-substituted-3,4,5,6-tetrachlorophthalimide using trichloroacetimidate C-C bond formation method

Walid Fathalla ¹

Ibrahim A. I. Ali ²

1. Department of Mathematics and Physical Sciences, Faculty of Engineering, Suez Canal University, Port Said, Egypt

2. Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt

Abstract

A series of N-substituted-3,4,5,6-tetrachlorophthalimides were prepared by a novel sequential reaction of trichloroacetimidate 3 with C-nucleophiles in the presence of TMSOTf. The nucleophiles include arenes, alkenes and active methylene to give the imidomethylation product of 3,4,5,6-tetrachlorophthalimide 5, 7, 9 and 11, respectively.

Keywords

Tetrachlorophthalimide

novel α-glucosidase inhibitors

trichloroacetimidate

C-C bond formation

C-nucleophiles

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