The impact of binary bioglass on the biodegradation and bio-mineralization of PCL electrospun fibers for guided bone regeneration

In this study, we produced Poly(ε-caprolactone) (PCL) electrospun fibers with varying concentrations (5%, 10%, 15%, and 20% wt. %) of binary bioactive glass 63S-37C (BG, 63% SiO2 - 37% CaO). These membranes showed good acellular bioactivity, biocompatibility, and reasonable biodegradability. Apatite formation in SBF was assessed using SEM-EDS analysis, indicating enhanced bioactivity with increased BG content. We also examined the effects of BG incorporation on membrane morphology, composition, fiber diameters, biodegradability, and bioactivity. Our findings demonstrate well-dispersed BG within the PCL matrix, maintaining thermal stability. Although PCL membranes were more hydrophobic than BG-filled ones, PCL/BG membranes displayed improved degradability, wettability, and enhanced apatite formation, especially with higher BG concentrations (10% and 20% wt. %). These results suggest that PCL/BG membranes hold promise for guided bone regeneration.

We focused on developing guided bone regeneration (GBR) membranes with enhanced bioactivity, biocompatibility, and proper degradation ability. By incorporating binary bioactive glass "63% SiO2 - 37% CaO" produced via a hydrothermal method into Poly(ε-caprolactone) (PCL) electrospun membranes, we aim to investigate their properties. The membranes aim to isolate bone defects from surrounding soft tissue, promoting bone tissue growth while preventing interference from non-osteogenic tissues. The impact of bioactive glass content on membrane properties, including wettability, biodegradation, and bio-mineralization, is examined to assess their potential applications in biomedical fields, particularly for guided bone regeneration.