Events The 4th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry

Published date

11 Sep, 2000

Citation

Matteo Zanda, Alessandro Volontiero, Pierfrancesco Bravo, Natalina Battista, Marcello Crucianelli, Facile and stereoselective synthesis of non-racemic trifluoroalanine, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01815

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Facile and stereoselective synthesis of non-racemic trifluoroalanine

Marcello Crucianelli ¹

Natalina Battista ¹

Pierfrancesco Bravo ²

Alessandro Volontiero ²

Matteo Zanda ²

1. Dipartimento di Chimica, Ingegneria Chimica e Materiali, Universita dell'Aquila, Via Vetoio, I-67010 Coppito, Italy

2. Dipartimento di Chimica del Politecnico, via Mancinelli 7, I-20131 Milano, Italy

Abstract

A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction of the sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5.

Keywords

n/a

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